Tyrphostin A9 Malonoben Cas 10537-47-0 Tyrosine Kinase Inhibitor
Tyrphostin A9 Malonoben Cas 10537-47-0 Tyrosine Kinase Inhibitor
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Chemical Information
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Product name:Tyrphostin A9 Malonoben |
Purity:98% min |
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CAS NO:10537-47-0 |
Solubility:DMSO50 mg/mL (177.07 mM) |
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Molecular Formula:C18H22N2O |
Package:Package according to customer requirements. |
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Molecular Weight:282.380 |
Storage:Store at -20℃ |
Quality control
Remarks
Tyrphostin A9(AG 17), a tyrosine kinase inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. IC50 value: Target: Multi tyrosine kinase Tyrphostin A9 inhibited TNF-induced tyrosine phosphorylation of pyk2 without blocking the cells' bactericidal activity. Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor (IC50 = 500 nM). Recent findings suggest that signaling via PDGF receptor tyrosine kinases is not necessary for the shift of the smooth muscle cells from a contractile to a synthetic phenotype. On the other hand these enzymes apparently carry out important functions in the control of intracellular membrane traffic and cell division.
Related Prodcuts:
LY2874455; ZM-306416; ZM323881; Orantinib; Brivanib; Foretinib; SU5402; Semaxanib; SAR131675; Lucitanib; Apatinib; SKLB610; Altiratinib; SGI-7079; AZD2932
References
[1].Park SJ, Park YJ, Shin JH, et al. A receptor tyrosine kinase inhibitor, Tyrphostin A9 induces cancer cell death through Drp1 dependent mitochondria fragmentation. Biochem Biophys Res Commun. 2011 May 13;408(3):465-70.
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