ZM323881 VEGFR Inhibitors CAS 193001-14-8 VEGF R2 Tyrosine Kinase In Vitro
ZM323881 VEGFR Inhibitors CAS 193001-14-8 VEGF R2 Tyrosine Kinase In Vitro
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Chemical Information
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Product name:ZM323881 |
Purity:98% min |
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CAS NO:193001-14-8 |
Solubility:Soluble in DMSO |
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Molecular Formula:C22H18FN3O2 |
Package:Package according to customer requirements |
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Molecular Weight:375.396 |
Storage:Store at -20℃ |
Quality control
Remarks
ZM323881 is a potent and selective inhibitor of VEGF-R2 tyrosine kinase in vitro (IC(50) < 2 nM), compared with other receptor tyrosine kinases, including VEGF-R1 (IC(50) > 50 microM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation (IC(50) = 8 nM) and VEGF-R2 tyrosine phosphorylation in vitro.
Related Prodcuts:
LY2874455; ZM-306416; ZM323881; Tyrphostin A9; Orantinib; Brivanib; Foretinib; SU5402; Semaxanib; SAR131675; Lucitanib; Apatinib; SKLB610; Altiratinib; SGI-7079; AZD2932
References
[1].Whittles CE, et al. ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity. Microcirculation. 2002 Dec;9(6):513-22.
[2].Endo A, et al. Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF. J Recept Signal Transduct Res. 2003;23(2-3):239-54.
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