FGF FGFR VEGFR Inhibitors LY2874455 Cas 1254473-64-7
FGF FGFR VEGFR Inhibitors LY2874455 Cas 1254473-64-7
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Chemical Information
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Product name:LY2874455 |
Purity:98% min |
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CAS NO:1254473-64-7 |
Solubility:DMSO50 mg/mL (112.53 mM) |
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Molecular Formula:C21H19Cl2N5O2 |
Package:Package according to customer requirements. |
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Molecular Weight:444.314 |
Storage:Store at -20℃ |
Quality control
Remarks
LY2874455 is a novel and potent FGF/FGFR Inhibitor. It exhibits a potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several tumor xenograft models representing the major FGF/FGFR relevant tumor histologies including lung, gastric, and bladder cancers and multiple myeloma, and with a well-defined pharmacokinetic/pharmacodynamic relationship.
Related Prodcuts:
ZM-306416; ZM323881; Tyrphostin A9; Orantinib; Brivanib; Foretinib; SU5402; Semaxanib; SAR131675; Lucitanib; Apatinib; SKLB610; Altiratinib; SGI-7079; AZD2932
References
[1] Zhao G, et al. Mol Cancer Ther. 2011, 10(11), 2200-2210.
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