Cas 883986-34-3 AZD2932 VEGFR Inhibitors For PDGFR Phosphorylation
Cas 883986-34-3 AZD2932 VEGFR Inhibitors For PDGFR Phosphorylation
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Chemical Information
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Product name:AZD2932 |
Purity:98% min |
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CAS NO:883986-34-3 |
Solubility:DMSO41 mg/mL (91.62 mM) |
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Molecular Formula:C24H25N5O4 |
Package:Package according to customer requirements |
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Molecular Weight:447.49 |
Storage:Store at -20℃ |
Quality control
Remarks
AZD2932 effectively inhibits the activities of VEGFR-2 (IC50, 8 nM), PDGFR (IC50,4 nM), Flt-3 (IC50, 7 nM), and c-Kit (IC50, 9 nM). AZD2932 inhibits both PDGFR and PDGFR phosphorylation with a correlation close to 1:1. AZD2932 does not inhibit the various cytochrome P450 isoforms with the worst IC50 being against 2C9 (8.0 M). AZD2932 has no activity against hERG (IC50, 137 M).
Related Prodcuts:
LY2874455; ZM-306416; ZM323881; Tyrphostin A9; Orantinib; Brivanib; Foretinib; SU5402; Semaxanib; SAR131675; Lucitanib; Apatinib; SKLB610; Altiratinib; SGI-7079
References
[1].Pl PA, et al. Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases. Bioorg Med Chem Lett. 2012 Jan 1;22(1):262-6.
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