Vandetanib ZD6474 VEGFR Inhibitors Cas 443913-73-3
Vandetanib ZD6474 VEGFR Inhibitors Cas 443913-73-3
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Chemical Information
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Product name:Vandetanib (ZD6474) |
Purity:98% min |
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CAS NO:443913-73-3 |
Solubility:DMSO27.5 mg/mL (57.85 mM) |
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Molecular Formula:C22H24BrFN4O2 |
Package:Packaging according to customer requirements |
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Molecular Weight:475.35 |
Storage:Store at -20℃ |
Quality control
Remarks
Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFR, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 M. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 M. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS).
Properties:
Appearance & Physical State: White solid
Density: 1.406
Boiling Point: 538.2C at 760 mmHg
Melting Point: 240-243C
Flash Point: 279.3C
Related Prodcuts:
Sorafenib; Cabozantinib; Cabozantinib malate; Ponatinib; Axitinib; Nintedanib; Regorafenib; Pazopanib HCl; Pazopanib; Cediranib; Dovitinib; Lenvatinib; Tivozanib; Sorafenib Tosylate; Sunitinib Malate
References
[1].Wedge SR, et al. ZD6474 inhibits vascular endothe
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