AZD-6094 Savolitinib Cas 1313725-88-0 Antineoplastic Activity
AZD-6094 Savolitinib Cas 1313725-88-0 Antineoplastic Activity
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- Prostaglandins - Custom Synthesis - PARP Inhibitors - PI3K Inhibitors - FAK Inhibitors - AKT Inhibitors - C-Kit Inhibitors - VEGFR Inhibitors - c-Met Inhibitors - CDK Inhibitors - CYP17 Inhibitors - DNA/RNA Inhibitors - mTOR Inhibitors - SRC Inhibitors - Others
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Chemical Information
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Product name:Savolitinib |
Purity:98% min |
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CAS NO:1313725-88-0 |
Solubility:DMSO25 mg/mL (72.39 mM; Need ultrasonic) |
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Molecular Formula:C17H15N9 |
Package:Package according to customer requirements |
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Molecular Weight:345.145 |
Storage:Store at -20℃ |
Quality control
Remarks
Savolitinib (AZD-6094) is a potent, highly selective, and orally bioavailable c-Met inhibitor with IC50s of 5 nM and 3 nM for c-Met and p-Met, respectively. Savolitinib (AZD-6094) selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. Antineoplastic activity.
References
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[1] Jia H, et al. J Med Chem. 2014, 57(18):7577-89.
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[2] Gavine PR, et al. Mol Oncol. 2015, 9(1):323-33.
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