Cas 1001917-37-8 MK-8033 C Met Inhibitors Small Molecule Inhibitor
Cas 1001917-37-8 MK-8033 C Met Inhibitors Small Molecule Inhibitor
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Chemical Information
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Product name:MK-8033 |
Purity:98% min |
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CAS NO:1001917-37-8 |
Solubility:DMSO46 mg/mL |
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Molecular Formula:C25H21N5O3S |
Package:Package according to customer requirements |
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Molecular Weight:471.531 |
Storage:Store at -20℃ |
Quality control
Remarks
MK8033 is a selective small-molecule inhibitor, ATP competitive. Phase I investigation of the cMet inhibitor MK-8033 is ongoing. Plans include a trial of this agent in refractory colorectal cancer, with pre- and post-treatment biopsies to evaluate for relevant molecular signatures.
Synonyms:
1-[2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide;
1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide;
Related Products
Capmatinib; Merestinib; SGX-523; MDK-0264; Tepotinib; NPS-1034; WYE-125132; PHA-665752; SCR-1481B1; SU11606
References
[1].Northrup AB, et al, Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated
[2].Bhardwaj V, et al. C-Met inhibitor MK-8003 radiosensitizes c-Met-expressing non-small-cell lung cancer cells with radiation-induced c-Met-expression. J Thorac Oncol. 2012 Aug;7(8):1211-7.
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