Capmatinib C Met Inhibitors INCB28060
Chemical Information
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Product name:Capmatinib INCB28060 |
Purity:98% min |
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CAS NO:1029712-80-8 |
Solubility:DMSO : 12.66 mg/mL (30.70 mM) |
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Molecular Formula:C23H17FN6O |
Package:Package according to customer requirements |
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Molecular Weight:412.419 |
Storage:Store at -20℃ |
Quality control
Remarks
Capmatinib, also known as INCB28060 and INC280, is an orally bioavailable inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. c-Met inhibitor INC280 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein.
Related Products:
MK-8033; Merestinib; SGX-523; MDK-0264; Tepotinib; NPS-1034; WYE-125132; PHA-665752; SCR-1481B1; SU11606
References
[1]. Liu X, et al. A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3. Clin Cancer Res. 2011 Nov 15;17(22):7127-38.
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