Cas 956905-27-4 PF-04217903 MET Tyrosine Kinase Inhibitor
Cas 956905-27-4 PF-04217903 MET Tyrosine Kinase Inhibitor
| Product name:PF-04217903 | Purity:98% min |
| CAS NO:956905-27-4 | Solubility:DMSO : 20 mg/mL (53.71 mM; Need ultrasonic) |
| Molecular Formula:C19H16N8O | Package:Package according to customer requirements |
| Molecular Weight:372.383 | Storage:Store at -20℃ |
PF-04217903 is a MET tyrosine kinase inhibitor, is also a n orally bioavailabe, small-molecule tyrosine kinase inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. c-Met inhibitor PF-04217903 selectively binds to and inhibits c-Met, disrupting the c-Met signaling pathway, which may result in the inhibition of tumor cell growth, migration and invasion of tumor cells, and the induction of death in tumor cells expressing c-Met.
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[1]. Timofeevski SL, et al. Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry, 2009, 48(23), 5339-5349.
[2]. Shojaei F, et al. HGF/c-Met acts as an alternative angiogenic pathway in sunitinib-resistant tumors. Cancer Res, 2010, 70(24), 10090-10100.
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