Cas 1957203-01-8 YKL-5-124 CDK7 Inhibitor C28H33N7O3
Cas 1957203-01-8 YKL-5-124 CDK7 Inhibitor C28H33N7O3
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Chemical Information
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Product name:YKL-5-124 |
Purity:98.0% min |
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CAS NO:1957203-01-8 |
Solubility:DMSO100 mg/mL (158.82 mM) |
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Molecular Formula:C28H33N7O3 |
Package:Package according to customer requirements |
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Molecular Weight:515.607 |
Storage:Store at -20℃ |
Quality control
Remarks
YKL-5-124 is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 TFA is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 TFA induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status.
CDK Inhibitors Related Products:
Palbociclib HCl; SNS-032; PF-00562271 Besylate; A-674563; NU6027; 1-NM-PP1; Trilaciclib; OTS964 HCl; Indisulam; Apcin;Palbociclib
References
[1].Olson CM, et al. Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype. Cell Chem Biol. 2019 Jun 20;26(6):792-803.e10.
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