Colon Cancer CDK9 Inhibitor JSH 150 Cas 2247481-21-4
Colon Cancer CDK9 Inhibitor JSH 150 Cas 2247481-21-4
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Chemical Information
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Product name:JSH-150 |
Purity:98% min |
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CAS NO:2247481-21-4 |
Solubility:DMSO33.33 mg/mL (67.93 mM) |
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Molecular Formula:C24H33ClN6O2S |
Package:Package according to customer requirements. |
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Molecular Weight:505.076 |
Storage:-20 ℃ |
Quality control
Remarks
JSH-150 is a potent CDK9 inhibitor. JSH-150 exhibited an IC50 of 1 nM against CDK9 kinase in the biochemical assay and achieved around 300-10000-fold selectivity over other CDK kinase family members. In addition, it also displayed high selectivity over other 468 kinases/mutants (KINOMEscan S score(1) = 0.
01). JSH-150displayed potent antiproliferative effects against melanoma, neuroblastoma, hepatoma, colon cancer, lung cancer as well as leukemia cell lines. It could dose-dependently inhibit the phosphorylation of RNA Pol II, suppress the expression of MCL-1 and c-Myc, arrest the cell cycle and induce the apoptosis in the leukemia cells.
Related Products
BMS-265246; LDC000067; Ribociclib; SU9516; Purvalanol A; Alvocidib; AZD-5597; Kenpaullone; ON123300; BS-181; Riviciclib
References
[1].Beilei Wang, et al. Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor. Eur J Med Chem. 13 September 2018.
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