98% Min Multikinase Inhibitor ON123300 Cas 1357470-29-1
98% Min Multikinase Inhibitor ON123300 Cas 1357470-29-1
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Chemical Information
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Product name:ON123300 |
Purity:98% min |
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CAS NO:1357470-29-1 |
Solubility:DMSO16.67 mg/mL (38.81 mM) |
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Molecular Formula:C24H27N7O |
Package:Package according to customer requirements |
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Molecular Weight:429.517 |
Storage:Store at -20℃ |
Quality control
Remarks
ON123300 is a potent multikinase inhibitor and may be potential useful for brain tumor chemotherapy. ON123300 strongly inhibits Ark5 and CDK4, as well as growth factor receptor tyrosine kinases such as -type platelet-derived growth factor receptor (PDGFR). ON123300 inhibits U87 glioma cell proliferation with an IC(50) 3.40.1 mol/L. ON123300 exhibits potent activity against mantle cell lymphomas (MCLs) both in vitro and in vivo. ON123300 might be an effective agent in MCL, including ibrutinib-resistant forms of the disease.
Properties:
Density: 1.357g/cm3
Boiling Point: 623.6C at 760 mmHg
Flash Point: 330.9C
Refractive Index: 1.603
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