NSC664704 Kenpaullone CDK Inhibitors Cas 142273-20-9
NSC664704 Kenpaullone CDK Inhibitors Cas 142273-20-9
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Chemical Information
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Product name:NSC664704 Kenpaullone |
Purity:98% min |
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CAS NO:142273-20-9 |
Solubility:DMSO35 mg/mL (106.97 mM) |
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Molecular Formula:C16H11BrN2O |
Package:Package according to customer requirements |
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Molecular Weight:327.175 |
Storage:Store at -20℃ |
Quality control
COA
Remarks
Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC50 = 400 nM), CDK2/cyclin A (IC50 = 680 nM), CDK2/cyclin E (IC50 = 7.5 uM) and CDK5/p25 (IC50 = 850 nM). Kenpaullone inhibits CDK2/cyclin A, CDK2/cyclin E and CDK5/cyclin/p35 (IC50 values are 0.68, 7.5 and 0.85 M respectively).
Related Products
BMS-265246; LDC000067; Ribociclib; SU9516; Purvalanol A; Alvocidib; AZD-5597; ON123300; BS-181; JSH-150; Riviciclib
References
[1].Zaharevitz DW, et al. Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res. 1999 Jun 1;59(11):2566-9.
[2].Lyssiotis CA, et al. Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8912-7.
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