CAS 924641-59-8 AZD-5597 CDK Inhibitor Antiproliferative
CAS 924641-59-8 AZD-5597 CDK Inhibitor Antiproliferative
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Chemical Information
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Product name:AZD-5597 |
Purity:98% min |
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CAS NO:924641-59-8 |
Solubility:Soluble in DMSO |
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Molecular Formula:C23H28FN7O |
Package:Package according to customer requirements |
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Molecular Weight:437.513 |
Storage:Store at -20℃ |
Quality control
Remarks
AZD-5597 is potent CDK inhibitor with in vitro anti-proliferative effects against a range of cancer cell lines. AZD-5597 has excellent physiochemical properties and large margins against inhibition of CYP isoforms and the hERG ion channel.
Related Products
BMS-265246; LDC000067; Ribociclib; SU9516; Purvalanol A; Alvocidib; Kenpaullone; ON123300; BS-181; JSH-150; Riviciclib
References
1. Inhibitors of protein kinase CDK9 for the treatment of NUT midline carcinomas. By Choidas, Axel; Klebl, Bert; Habenberger, Peter; Eickhoff, Jan; Thomas, Roman; Heuckmann, Johannes. From PCT Int. Appl. (2013), WO 2013026874 A1 20130228,
2. Susceptibility of tumor cells to selective CDK9 kinase inhibitors for predicting treatment of NUT midline carcinoma. By Choidas, Axel; Klebl, Bert; Habenberger, Peter; Eickhoff, Jan; Thomas, Roman; Heuckmann, Johannes. From PCT Int. Appl. (2013), WO 2013026890 A1 20130228,
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