anticancer CDK Inhibitors RO-3306 Cas 872573-93-8
Anticancer CDK Inhibitors RO-3306 Cas 872573-93-8
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Chemical Information
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Product name:RO-3306 |
Purity:98% min |
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CAS NO:872573-93-8 |
Solubility:DMSO47 mg/mL (133.73 mM) |
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Molecular Formula:C18H13N3OS2 |
Package:Package according to customer requirements |
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Molecular Weight:351.445 |
Storage:Store at -20℃ |
Quality control
Remarks
RO-3306 is a CDK1 inhibitor with potential anticancer activity. Treatment of growing AML cells with RO-3306 induced G2/M-phase cell cycle arrest and apoptosis in a dose- and time-dependent manner. RO-3306 downregulated expression of the antiapoptotic proteins Bcl-2 and survivin and blocked p53-mediated induction of p21 and MDM2. RO-3306 actively enhances downstream p53 signaling to promote apoptosis.
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Flavopiridol HCL; Flavopiridol; THZ1; BMS-863233 HCl; Dinaciclib; AZD5438; Seliciclib; Palbociclib Isethionate; PHA-793887; Abemaciclib mesylate; Abemaciclib; JNJ-7706621
References
[1].Vassilev LT, et al. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10660-5.
[2].Kojima K, et al. Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. Cancer Sci. 2009 Jun;100(6):1128-36.
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