K-858 Racemic cas 72926-24-0
Price:
Negotiable
MOQ:
1g
Delivery Time:
Negotiable
Brand:
Crene
Product Description
Chemical Information
| Product name:K-858 Racemic | Purity:98% min |
| CAS NO:72926-24-0 | Solubility:DMSO : 100 mg/mL (360.57 mM); H2O : < 0.1 mg/mL |
| Molecular Formula:C13H15N3O2S | Package:Package according to customer requirements |
| Molecular Weight:277.342 | Storage:Store at +4°C |
Remarks
K-858 is a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. K858 blocked centrosome separation, activated the spindle checkpoint, and induced mitotic arrest in cells accompanied by the formation of monopolar spindles. Long-term continuous treatment of cancer cells with K858 resulted in antiproliferative effects through the induction of mitotic cell death, and polyploidization followed by senescence. K858 exhibited potent antitumor activity in xenograft models of cancer, and induced the accumulation of mitotic cells with monopolar spindles in tumor tissues.
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Company
Taizhou Crene Biotechnology Co., Ltd.
Location
Add: Economic Developed Zone of Taizhou Zhejiang China.