CB-5083 cas 1542705-92-9
| Product name:CB-5083 | Purity:98% min |
| CAS NO:1542705-92-9 | Solubility:DMSO : ≥ 100 mg/mL (241.86 mM) |
| Molecular Formula:C24H23N5O2 | Package:Package according to customer requirements |
| Molecular Weight:413.472 | Storage:Store at -20℃ |
CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . CB-5083 causes rapid and sustained accumulation of poly-ubiquitin in tumor xenografts after a single administration. CB-5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB-5083 appears to exhibit greater potency over current proteasome inhibitors that further validate targeting p97 and protein homeostasis in the treatment of cancer.
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