Benzamide 4SC-202 Domatinostat Cas 910462-43-0
Benzamide 4SC-202 Domatinostat Cas 910462-43-0
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Chemical Information
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Product name:4SC-202 Domatinostat |
Purity:98% min |
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CAS NO:910462-43-0 |
Solubility:DMSO58 mg/mL (129.61 mM) |
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Molecular Formula:C23H21N5O3S |
Package:Package according to customer requirements |
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Molecular Weight:447.510 |
Storage:Store at -20℃ |
Quality control
Remarks
4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, the selective transcription of tumor suppressor genes, and the tumor suppressor protein-mediated inhibition of tumor cell division and eventually the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins.
References
[1].Pinkerneil M, et al. Evaluation of the Therapeutic Potential of the Novel Isotype Specific HDAC Inhibitor 4SC-202 in Urothelial Carcinoma Cell Lines. Target Oncol. 2016 Dec;11(6):783-798.
[2].Zhijun H, et al. Pre-clinical characterization of 4SC-202, a novel class I HDAC inhibitor, against colorectal cancer cells. Tumour Biol. 2016 Aug;37(8):10257-67.
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