BMH-21 Small Molecule DNA Intercalator Cas 896705-16-1
BMH-21 small molecule DNA Intercalator Cas 896705-16-1
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Chemical Information
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Product name:BMH-21 |
Purity:98% min |
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CAS NO:896705-16-1 |
Solubility:DMSO1 mg/mL (2.77 mM) |
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Molecular Formula:C21H20N4O2 |
Package:Package according to customer requirements |
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Molecular Weight:360.409 |
Storage:Store at -20℃ |
Quality control
Remarks
BMH-21 is a potent small molecule DNA intercalator. BMH-21 binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. BMH-21 does not cause phosphorylation of H2AX, a key biomarker activated in DNA damage stress. BMH-21 effects on the nucleolar stress response were independent of major DNA damage associated PI3-kinase pathways, ATM, ATR and DNA-PKcs. BMH-21 is a chemically unique DNA intercalator that has high bioactivity towards Pol I inhibition without activation or dependence of DNA damage stress. The findings also show that interference with DNA and DNA metabolic processes can be exploited therapeutically without causing DNA damage.
Related Prodcuts:
Etoposide; Etoposide phosphate; ML-323; Nexturastat A; TMP269; GSK2606414; ELR510444; Chidamide; Inauhzin; CW069; Purvalanol A; Purvalanol B; JW55; Tenovin-6; Tenovin-6 HCL; RKI-1447; AZD2461; Tasquinimod
References
[1].Colis L, et al. DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response. Oncotarget. 2014 Jun 30;5(12):4361-9.
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