Usp1 Uaf1 DNA Synthesis Inhibitors Ml-323 Cas 1572414-83-5
Usp1 Uaf1 DNA Synthesis Inhibitors Ml-323 Cas 1572414-83-5
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Chemical Information
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Product name:ML-323 |
Purity:98% min |
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CAS NO:1572414-83-5 |
Solubility:DMSO49 mg/mL (127.44 mM) |
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Molecular Formula:C23H24N6 |
Package:Package according to customer requirements. |
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Molecular Weight:384.477 |
Storage:Store at -20℃ |
Quality control
COA
Remarks
ML323 is a selective and highly potent USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. ML323 inhibits the USP1-UAF1 deubiquitinase complex with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases. ML323 potentiates cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells. USP1-UAF1 is a key regulator of the DNA damage response and a target for overcoming resistance to the platinum-based anticancer drugs.
Related Prodcuts:
Etoposide; Etoposide phosphate; BMH-21; Nexturastat A; TMP269; GSK2606414; ELR510444; Chidamide; Inauhzin; CW069; Purvalanol A; Purvalanol B; JW55; Tenovin-6; Tenovin-6 HCL; RKI-1447; AZD2461; Tasquinimod
References
[1].Liang Q, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol. 2014 Apr;10(4):298-304.
[2].Dexheimer TS, et al. Discovery of ML323 as a Novel Inhibitor of the USP1/UAF1 Deubiquitinase Complex. National Center for Biotechnology In
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