Semisynthetic DNA RNA Inhibitors Etoposide Cas 33419-42-0
Semisynthetic DNA RNA Inhibitors Etoposide Cas 33419-42-0
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Chemical Information
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Product name:Etoposide |
Purity:98% min |
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CAS NO:33419-42-0 |
Solubility:DMSO39 mg/mL |
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Molecular Formula:C29H32O13 |
Package:Package according to customer requirements |
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Molecular Weight:588.557 |
Storage:Store at -20℃ |
Quality control
COA
Remarks
Etoposide is a semisynthetic derivative of podophyllotoxin and a substance extracted from the mandrake root Podophyllum peltatum. Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
Related Prodcuts:
Etoposide phosphate; ML-323; BMH-21; Nexturastat A; TMP269; GSK2606414; ELR510444; Chidamide; Inauhzin; CW069; Purvalanol A; Purvalanol B; JW55; Tenovin-6; Tenovin-6 HCL; RKI-1447; AZD2461; Tasquinimod
References
[1].Lee KI, et al. Etoposide induces pancreatic -cells cytotoxicity via the JNK/ERK/GSK-3 signaling-mediated mitochondria-dependent apoptosis pathway. Toxicol In Vitro. 2016 Jul 26. pii: S0887-2333(16)30147-3.
[2].Calvani M, det al. Etoposide-Bevacizumab a new strategy against huma
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