PAK4 DNA Synthesis Inhibitors PF-3758309 Cas 898044-15-0
PAK4 DNA Synthesis Inhibitors PF-3758309 Cas 898044-15-0
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Chemical Information
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Product name:PF-3758309 |
Purity:98% min |
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CAS NO:898044-15-0 |
Solubility:DMSO100 mg/mL (203.82 mM) |
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Molecular Formula:C25H30N8OS |
Package:Package according to customer requirements |
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Molecular Weight:490.624 |
Storage:Store at -20℃ |
Quality control
Remarks
PF-3758309, also known as PF-03758309, is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.
Related Prodcuts:
Fidaxomicin; Marbofloxacin; CP-466722; TTP 22; D-64131; M344; CHIR-124; Reversine; Pralatrexate; XL228; VE-822; RI-1; SRPIN340; XL888; Rigosertib; APY29; NMS-873; Telatinib
References
[1].Murray, Brion W., et al. Small-molecule p21-activated kinase inhibitor PF3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proceedings of the National Academy of Sciences of the United States of America (2010), 107(20), 9446-9451, S94
[2].Zhao ZS, et al. Do
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