Taizhou Crene Biotechnology Co., Ltd.
                                                                                                           
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China NMS-873 cas 1418013-75-8 for sale

NMS-873 cas 1418013-75-8

Price Negotiable
Price: Negotiable
MOQ: 1g
Delivery Time: Negotiable
Brand: Crene
Product Description
Chemical Information
Product name:NMS-873 Purity:98% min
CAS NO:1418013-75-8 Solubility:DMSO : 20.5 mg/mL (39.37 mM)
Molecular Formula:C27H28N4O3S2 Package:Package according to customer requirements
Molecular Weight:520.666 Storage:Store at -20℃
Remarks

NMS-873 is a potent, allosteric and specific VCP inhibitor (also known as p97 inhibitor) with IC50 of 30 nM. NMS-873 activated the unfolded protein response, interfered with autophagy and induced cancer cell death. The consistent pattern of cancer cell killing by covalent and allosteric inhibitors provided critical validation of VCP as a cancer target.

 

 

 

 

Related Prodcuts:

Fidaxomicin; Marbofloxacin; CP-466722; TTP 22; D-64131; M344; CHIR-124; Reversine; Pralatrexate; XL228; VE-822; RI-1; SRPIN340; XL888; Rigosertib; APY29; PF-03758309; Telatinib

References
[1]. Paola Magnaghi, et al. Covalent and allosteric inhibitors of the ATPATP ase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Jul 28. doi: 10.1038/nchembio.1313.
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Company Taizhou Crene Biotechnology Co., Ltd.
Location Add: Economic Developed Zone of Taizhou Zhejiang China.

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