RI-1 cas 415713-60-9
| Product name:RI-1 | Purity:98% min |
| CAS NO:415713-60-9 | Solubility:DMSO : 33.33 mg/mL (92.17 mM) |
| Molecular Formula:C14H11Cl3N2O3 | Package:Package according to customer requirements |
| Molecular Weight:361.608 | Storage:Store at -20℃ |
RI-1 is an irreversible inhibitor of RAD51 (IC50s = 5-30 µM), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types. RI-1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into filaments on DNA. RI-1 holds promise as an oncologic drug. Furthermore, RI-1 represents a unique tool to dissect the network of reaction pathways that contribute to DNA repair in cells.
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