Small Molecule Chk1 Inhibitor CHIR-124 Cas 405168-58-3
Small Molecule Chk1 Inhibitor CHIR-124 Cas 405168-58-3
Product
| Size | Price | Stock | Quantity |
|---|---|---|---|
| Get Quotation Now Add to Cart Bulk Inquiry | |||
AddThis Sharing Buttons
| Product name:CHIR-124 | Purity:98% min |
| CAS NO:405168-58-3 | Solubility:DMSO14 mg/mL (33.34 mM) |
| Molecular Formula:C23H22ClN5O | Package:Package according to customer requirements |
| Molecular Weight:419.907 | Storage:Store at -20℃ |
CHIR-124 is a quinolone-based small molecule Chk1 inhibitor, that is structurally unrelated to other known inhibitors of Chk1. It potently and selectively inhibits Chk1 in vitro (IC(50) = 0.0003 micromol/L). CHIR-124 interacts synergistically with topoisomerase poisons (e.g., camptothecin or SN-38) in causing growth inhibition in several p53-mutant solid tumor cell lines as determined by isobologram or response surface analysis. CHIR-124 is a novel and potent Chk1 inhibitor with promising antitumor activities when used in combination with topoisomerase I poisons.
Related Prodcuts:
Fidaxomicin; Marbofloxacin; CP-466722; TTP 22; D-64131; M344; Reversine; Pralatrexate; XL228; VE-822; RI-1; SRPIN340; XL888; Rigosertib; APY29; NMS-873; PF-03758309; Telatinib
[1].Tse AN, et al. CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo. Clin Cancer Res, 2007, 13(2 Pt 1), 591-602.
[2].Dai Y, e
Get in Touch
Have questions about our products or want to discuss a custom order? Our team is ready to help you.