Tubulin DNA Synthesis Inhibitors D 64131 Cas 74588-78-6
Tubulin DNA Synthesis Inhibitors D 64131 Cas 74588-78-6
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Chemical Information
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Product name:D-64131 |
Purity:98% min |
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CAS NO:74588-78-6 |
Solubility:DMSO100 mg/mL (397.96 mM) |
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Molecular Formula:C16H13NO2 |
Package:Package according to customer requirements |
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Molecular Weight:251.28 |
Storage:Store at -20℃ |
Quality control
Remarks
D-64131 is a potent and selective tubulin inhibitor. D-64131 inhibits tumor cell proliferation in vitro (IC50 = 74 nM). In xenograft experiments with the human amelanoic melanoma MEXF 989, D-64131 was highly active with treatment resulting in a growth delay of 23.4 days at 400 mg/kg.
Related Prodcuts:
Fidaxomicin; Marbofloxacin; CP-466722; TTP 22; M344; CHIR-124; Reversine; Pralatrexate; XL228; VE-822; RI-1; SRPIN340; XL888; Rigosertib; APY29; NMS-873; PF-03758309; Telatinib
References
[1].Mahboobi, Siavosh; Pongratz, Herwig; Hufsky, Harald et al. Synthetic 2-Aroylindole Derivatives as a New Class of Potent Tubulin-Inhibitory, Antimitotic Agents. Journal of Medicinal Chemistry (2001), 44(26), 4535-4553.
[2].Bacher, G.; Beckers, T.; Emig, P. et al. New small-molecule tubulin inhibitors. Pure and Applied Chemistry (2001), 73(9), 1459-1464.
[3].Beckers, Thomas; Reissmann, Thomas; Schmidt, Mathias et al. 2
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