Mitomycin C Cas 50-07-7 Methyl Azirin Pyrrolo Indole Dione

Mitomycine C is a methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. Check for active clinical trials or closed clinical trials using this agent.

Properties:
Appearance & Physical State: dark blue grey crystalline powder
Density: 1.56g/cm3
Melting Point: 360ºC
Boiling Point: 581.8ºC at 760mmHg
Flash Point: 305.6ºC
Refractive Index: 1.68
Water Solubility: soluble
Stability: Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.

Related Prodcuts:

Talazoparib; Aleglitazar; Miriplatin; Scriptaid; Ceritinib; CGK733; Tacedinaline; P005091; PR-619; Gemcitabine; Gemcitabine HCL; Terbinafine hydrochloride; Clevudine; Givinostat hydrochloride monohydrate

[1]. Cheng H, et al. Mitomycin C potentiates TRAIL-induced apoptosis through p53-independent upregulation of death receptors: Evidence for the role of c-Jun N-terminal kinase activation. Cell Cycle. 2012 Sep 1;11(17): 3312-23.

[2]. Abbas T, et al. Differential activation of p53 by the various adducts of mitomycin C. J Biol Chem. 2002 Oct 25;277(43):40513-9.