ATR ATM Inhibitor CGK733 Cas 905973-89-9
ATR ATM Inhibitor CGK733 Cas 905973-89-9
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Chemical Information
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Product name:CGK733 |
Purity:98% min |
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CAS NO:905973-89-9 |
Solubility:DMSO100 mg/mL (179.91 mM) |
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Molecular Formula:C23H18Cl3FN4O3S |
Package:Package according to customer requirements |
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Molecular Weight:555.836 |
Storage:Store at -20℃ |
Quality control
Remarks
CGK733 is an ATM inhibitor and ATR inhibitor, which significantly enhanced taxol-induced cytotoxicity in HBV-positive HepG2.2.15 cells. The mechanism lies in CGK733 triggers the formation of multinucleated cells thus promotes the premature mitotic exit of taxol-induced mitotic-damaged cells through multinucleation and mitotic catastrophe in HBV-positive HepG2.2.15 cells. These results suggest that CGK733 could potentially reverse the taxol resistance in HBV-positive HCC cells and may suggest a novel strategy to treat HBV-infected HCC patients.
Related Prodcuts:
Talazoparib; Aleglitazar; Miriplatin; Scriptaid; Ceritinib; Tacedinaline; P005091; PR-619; Gemcitabine; Gemcitabine HCL; Terbinafine hydrochloride; Mitomycin C; Clevudine; Givinostat hydrochloride monohydrate
References
[1].Wang H, et al. CGK733 enhances multinucleated cell formation and cytotoxicity induced by taxol in Chk1-deficient HBV-positive hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2012 May 25;422(1):103-8.
[2].Alao JP, et al. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat Oncol. 2009 Nov 10;4:51.
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