Fotemustine cas 92118-27-9

Name: Fotemustine cas 92118-27-9
Brand: Taizhou Crene Biotechnology Co., Ltd.

Price Negotiable

Price: Negotiable

MOQ: 1g

Delivery Time: Negotiable

Brand: Crene

Product Description

Chemical Information

Product name:Fotemustine	Purity:98% min
CAS NO:92118-27-9	Solubility:DMSO : ≥ 3.2 mg/mL (10.14 mM)
Molecular Formula:C₉H₁₉ClN₃O₅P	Package:Packaging according to customer requirements
Molecular Weight:315.691	Storage:Store at -20℃

Remarks

Fotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

References

[1]. Brakenhoff JP, et al. Molecular mechanisms of toxic effects of fotemustine in rat hepatocytes and subcellular rat liver fractions. Carcinogenesis. 1996 Apr;17(4):715-24.

[2]. Merlin JL, et al. Enhancement of fotemustine (Muphoran) cytotoxicity by amifostine in malignant melanoma cell lines. Anticancer Drugs. 2002 Feb;13(2):141-7.