Cidofovir Dihydrate Vistide DNA Inhibitors Cas 149394-66-1
Cidofovir Dihydrate Vistide DNA Inhibitors Cas 149394-66-1
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Chemical Information
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Product name:Cidofovir dihydrate |
Purity:98% min |
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CAS NO:149394-66-1 |
Solubility:Soluble in DMSO |
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Molecular Formula:C8H14N3O6P |
Package:Package according to customer requirements |
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Molecular Weight:279.187 |
Storage:Store at -20℃ |
Quality control
Remarks
Cidofovir, also known as Vistide, is an injectable antiviral medication primarily used as a treatment for cytomegalovirus (CMV) retinitis- an infection of the retina of the eye in people with AIDS.Cidofovir is an acyclic nucleoside phosphonate. In vitro, cidofovir is converted to cidofovir diphosphate which incorporates into viral DNA, selectively inhibiting CMV replication and CMV DNA synthesis with IC50 values of 0.1 M. Cidofovir has significantly long-lasting antiviral action because of the long half-life of its metabolites whose cellular uptake is slow due to the presence of the negatively charged phosphonate group. It has also demonstrated remarkable activity as an antitumor agent in a variety of animal models of tumor growth.
Related Products:
Vinorelbine Tartrate; Vinblastine sulfate; Vinflunine; NU7441; Volasertib; TAK-901; Cidofovir;Pixantrone; Pixantrone dimaleate; Fludarabine; Fludarabine Phosphate; Clofarabine; Nelarabine; Vorinostat
References
[1].Becker MN, et al. Isolation and characterization of cidofovir resistant vaccinia viruses. Virol J. 2008 May 14;5:58.
[2].Kazory A, et al. Simultaneous development of Fanconi syndrome and acute renal failure associated with cidofovir. J Antimicrob Chemother. 2007 Jul;60(1):193-4. Epub 2007 May 11.
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