Taizhou Crene Biotechnology Co., Ltd.
                                                                                                           
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China MK-5108 VX-689 cas 1010085-13-8 for sale

MK-5108 VX-689 cas 1010085-13-8

Price Negotiable
Price: Negotiable
MOQ: 1g
Delivery Time: Negotiable
Brand: Crene
Product Description
Chemical Information
Product name:MK-5108 VX-689 Purity:98% min
CAS NO:1010085-13-8 Solubility:DMSO : 6.4 mg/mL (13.85 mM)
Molecular Formula:C22H21ClFN3O3S Package:Package according to customer requirements
Molecular Weight:461.937 Storage:Store at -20℃
Remarks

MK-5108, also known as VX689, is a novel small molecule with potent inhibitory activity against Aurora-A kinase. MK-5108 specifically inhibited Aurora-A kinase in a panel of protein kinase assays. MK-5108 also induced phosphorylated Histone H3 in skin and xenograft tumor tissues in a nude rat xenograft model. MK-5108 inhibited growth of human tumor cell lines in culture and in different xenograft models. MK-5108 is currently tested in clinical trials and offers a new therapeutic approach to combat human cancers as a single agent or in combination with existing taxane therapies.

 

 

 

Related Products:

SRT1720 hcl; Barasertib; ABT-751; SNS-314; SNS-314 mesylate; Alisertib; Abexinostat; Romidepsin; R547; Tubastatin A HCL; SCH900776; PF00477736; GW7647; Dalcetrapib

References
[1]. Shimomura T, et al. MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel. Mol Cancer Ther. 2010 Jan;9(1):157-66.
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Company Taizhou Crene Biotechnology Co., Ltd.
Location Add: Economic Developed Zone of Taizhou Zhejiang China.

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