Nimustine Hydrochloride cas 55661-38-6

Nimustine Hydrochloride is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.

Synonyms:

nimustinaclorhidrato;

cs-439;

1-(4-Amino-2-methyl-5-pyrimidinyl)-1-methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride;

1-((4-amino-2-methyl-5-pyrimidinyl)methyl)-3-(2-chloroethyl)-3-nitrosoure hydrochloride;

ACNU;

Nimustine hydrochloride;

nidran;

NIMUSTINE HCL;

3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-1-(2-chloroethyl)-1-nitroso-ure;

4-amino-5-({[N-(2-chloroethyl)-N-nitrosocarbamoyl]amino}methyl)-2-methylpyrimidin-1-ium chloride;

Related Products:

Pritelivir mesylate; Capecitabine; Lomustine; Thiotepa; KU-55933; Ganetespib; Onalespib; INNO-206 HCl salt; Aldoxorubicin; Pritelivir

[1]. Tomicic MT, et al. Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM. Oncotarget. 2015 Oct 20;6(32):33755-68.

[2]. Kondo N, et al. FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ. PLoS One. 2011 May 9;6(5):e19659.