Cladribine cas 4291-63-8

Cladribine is a purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity.

Properties:

Appearance & Physical State: White Crystalline Solid

Density: 2.03g/cm3

Boiling Point: 547.6ºC at 760 mmHg

Melting Point: 181-185ºC(lit.)

Flash Point: 285ºC

Related Prodcuts:

Cisplatin; Gemcitabine HCL; Bleomycin Sulfate; Temozolomide; Carmustine; CX-5461; Fludarabine Phosphate; Nelarabine; Trifluridine; Daptomycin

[1] Ma J, et al. BMC Cancer. 2011, 11, 255.

[2] Guchelaar HJ, et al. Cancer Chemother Pharmacol. 1998, 42(1), 77-83.

[3] B?hm A, et al. Exp Hematol. 2010, 38(9), 744-755.