Fludarabine Phosphate DNA Synthesis Inhibitors Cas 75607-67-9
Fludarabine Phosphate DNA Synthesis Inhibitors Cas 75607-67-9
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Chemical Information
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Product name:Fludarabine Phosphate |
Purity:98% min |
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CAS NO:75607-67-9 |
Solubility:DMSO100 mg/mL (273.82 mM) |
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Molecular Formula:C10H13FN5O7P |
Package:Packaging according to customer requirements |
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Molecular Weight:365.21 |
Storage:Store at -20℃ |
Quality control
COA
Remarks
Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
Fludarabine Phosphate is converted to F-ara-ATP in cells and then incorporated into DNA in a self-limiting manner. Fludarabine Phosphate competes with dATP for incorporation into the A site of the extending DNA strand, which results in termination of DNA strand elongation. Human DNA polymerase incorporates more Fludarabine Phosphate into DNA than polymerase . Fludarabine Phosphate completively inhibits DNA polymerase and DNA polymerase with Kiof 1.1 M and 1.3 M, respectively. DNA polymerase is also able to excise the incorporated Fludarabine Phosphate from DNA in vitro.
Properties:
Density2.39 g/cm3
Boiling Point: 864.2C at 760 mmHg
Flash Point: 476.4C
Refractive Index: 1.878
Related Prodcuts:
Cisplatin; Gemcitabine HCL; Bleomycin Sulfate; Temozolomide; Carmustine; CX-5461; Nelarabine; Cladribine;Trifluridine; Daptomycin; Vorinostat
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