Carmustine cas 154-93-8

Carmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a medication used mainly for chemotherapy and sometimes for immunosuppression before organ transplantation. It is a nitrogen mustard β-chloro-nitrosourea compound used as an alkylating agent. As a dialkylating agent, BCNU is able to form interstrand crosslinks in DNA, which prevents DNA replication and DNA transcription.

It has the appearance of an orange-yellow solid.

Carmustine for injection was earlier marketed under the name BiCNU by Bristol-Myers Squibb and now by Emcure Pharmaceuticals. In India it is sold under various brand names, including Consium.

Properties:

Appearance & Physical State: Orange-yellow solid.

Density: 1.46 g/ml

Boiling Point: 404ºC

Melting Point: 30ºC

Refractive Index: 1.548

Related Prodcuts:

Cisplatin; Gemcitabine HCL; Bleomycin Sulfate; Temozolomide; CX-5461; Fludarabine Phosphate; Nelarabine; Cladribine; Trifluridine; Daptomycin

[1]. http://www.drugbank.ca/drugs/DB00262

[2]. Lin, S.H. and L.R. Kleinberg, Carmustine wafers: localized delivery of chemotherapeutic agents in CNS malignancies. Expert Rev Anticancer Ther, 2008. 8(3): p. 343-59.