Fda Approved Mtor Inhibitors PF-4708671 Cas 1255517-76-0
Fda Approved Mtor Inhibitors PF-4708671 Cas 1255517-76-0
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Chemical Information
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Product name:PF-4708671 |
Purity:98% min |
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CAS NO:1255517-76-0 |
Solubility:DMSO33.33 mg/mL (85.37 mM) |
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Molecular Formula:C19H21F3N6 |
Package:Package according to customer requirements |
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Molecular Weight:390.405 |
Storage:Store at +4°C |
Quality control
Remarks
PF-4708671 is a novel cell-permeable inhibitor of S6K1. PF-4708671 specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases.
S6 Kinase Inhibitors Related Prodcuts:
BI-D1870; AT7867; H-89; H-89 2HCl; Staurosporine; Pluripotin; LY-2584702; AT13148; Bosutinib
References
[1].Pearce LR, et al. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55.
[2].Zhang Y, et al. Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells. Mol Cancer Ther. 2015 Mar;14(3):799-809.
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