Synthesis MTOR Inhibitors Torin 2 Cas 1223001-51-1
Synthesis MTOR Inhibitors Torin 2 Cas 1223001-51-1
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Chemical Information
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Product name:Torin 2 |
Purity:98% min |
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CAS NO:1223001-51-1 |
Solubility:DMSO≥30 mg/mL (69.38 mM) |
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Molecular Formula:C24H15F3N4O |
Package:Packaging according to customer requirements. |
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Molecular Weight:432.4 |
Storage:Store at -20℃ |
Quality control
Remarks
Torin 2 is a potent and selectivemTORinhibitor withIC50of 0.25 nM in p53/ MEFs cell line; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition ofATM/ATR/DNA-PKwithEC50of 28 nM/35 nM/118 nM,in PC3 cell lines respectively.
Torin 2 has the same binding mode as PI3K, V882 serves as a hinge binding point and in the inner hydrophobic pocket Y867, D841 and D964 provide three more hydrogen bonds with aminopyridine side chain analogous to Y2225, D2195 and D2357 of mTOR.Torin 2 inhibits mTORC1, thus activates TFEB by promoting its nuclear translocation with EC50 of 1.666 mM.Torin 2(< 50 nM) causes a significant reduction in viability of both MZ-CRC-1 and TT cells. Torin 2 (100 nM) exerts a significant reduction of migration of both MZ-CRC-1 and TT cells.
Properties:
Density: 1.427 g/cm3
Boiling Point: 623.66C at 760 mmHg
Flash Point: 330.978C
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