Tacrolimus FK506 FR900506 Fujimycin Prograf Cas 104987-11-3

Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.

Properties:

Appearance & Physical State: White or off-white crystalline powder

Density: 1.19 g/cm3

Boiling Point: 871.7ºC at 760 mmHg

Melting Point: 113-115ºC

Flash Point: 481ºC

Refractive Index: 1.549

Storage Condition: -20ºC

Vapor Pressure: 1.73E-35mmHg at 25°C

Related Products:

Everolimus; Temsirolimus; PI-103; Torin 1; PF-04691502; Apitolisib; Torin 2; BGT226; Palomid 529; Deforolimus; KU-0063794; Rapamycin; Tacrolimus monohydrate

[1] Flanagan WM, et al. Nature, 1991, 352(6338), 803-807.

[2] O'Keefe SJ, et al. Nature, 1992, 357(6380), 692-694.

[3] Fruman DA, et al. Proc Natl Acad Sci U S A, 1992, 89(9), 3686-3690.