TPX-0005 Ropotrectinib TRK Inhibitor Cas 1802220-02-5
TPX-0005 Ropotrectinib TRK Inhibitor Cas 1802220-02-5
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Chemical Information
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Product name:TPX-0005 Ropotrectinib |
Purity:99% min |
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CAS NO:1802220-02-5 |
Solubility:DMSO83.3 mg/mL (234.40 mM) |
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Molecular Formula:C18H18FN5O2 |
Package:Packaging according to customer requirements |
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Molecular Weight:355.3734 |
Storage:Store at -20℃ |
Quality control
Remarks
Ropotrectinib, also known as TPX-0005, is a potent ALK/ROS-1/TRK inhibitor. TPX-0005 plus EGFR TKI suppressed expression and activation of RTKs and downstream signaling intermediates. Co-expression of CDCP1 and AXL is often observed in EGFR-mutation-positive tumors, limiting the efficacy of EGFR TKIs. Co-treatment with EGFR TKI and TPX-0005 warrants testing.
Related Products
Afatinib dimaleate; Neratinib; Bosutinib; Bosutinib Intermediates; Bosutinib Monohydrate; Saracatinib; Dasatinib; NVP-BHG712; PP1; PP2; A-966492; G007-LK; SU6656; Tirbanibulin; Afatinib
References
[1].Dayong Zhai, et al. Abstract 2132: The novel, rationally-designed, ALK/SRC inhibitor TPX-0005 overcomes multiple acquired resistance mechanisms to current ALK inhibitors. Cancer Research. July 2016
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