98% min SRC Inhibitors PP2 AGL 1879 Cas 172889-27-9
98% min SRC Inhibitors PP2 AGL 1879 Cas 172889-27-9
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Chemical Information
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Product name:PP2 AGL 1879 |
Purity:98% min |
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CAS NO:172889-27-9 |
Solubility:DMSO50 mg/mL (165.69 mM); H2O< 0.1 mg/mL |
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Molecular Formula:C15H16ClN5 |
Package:Package according to customer requirements |
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Molecular Weight:301.774 |
Storage:Store at -20℃ |
Quality control
Remarks
PP2, also known as AG 1879, is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100 M) and JAK2 (50 M). Despite its extensive use as a Src-selective inhibitor, recent research has shown that PP2 is non-selective and inhibits many other kinases with similar affinities.
Properties:
Appearance & Physical State: White solid
Density: 1.35 g/cm3
Boiling Point: 493.5C at 760 mmHg
Melting Point: 214-216C
Flash Point: 252.3C
Refractive Index: 1.676
Vapor Pressure: 6.98E-10mmHg at 25°C
Related Products
Afatinib dimaleate; Neratinib; Bosutinib; Bosutinib Intermediates; Bosutinib Monohydrate; Saracatinib; Dasatinib; NVP-BHG712; PP1; A-966492; G007-LK; SU6656; Tirbanibulin; TPX-0005; Afatinib
References
[1].Hanke JH, et al. Discovery of
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