PP1 AGL 1872 SRC Inhibitors Cas 172889-26-8
PP1 AGL 1872 SRC Inhibitors Cas 172889-26-8
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Chemical Information
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Product name:PP1 AGL 1872 |
Purity:98% min |
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CAS NO:172889-26-8 |
Solubility:DMSO28 mg/mL (99.52 mM) |
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Molecular Formula:C16H19N5 |
Package:Package according to customer requirements |
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Molecular Weight:281.356 |
Storage:Store at -20℃ |
Quality control
Remarks
PP1 is a potent and selective Src family protein tyrosine kinase inhibitor. PP1 effectively blocks TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells. PP1 blocks TGF-beta1-mediated cellular responses by direct and differential inhibition of type I and type II TGF-beta receptors. PP1 was also found to potentiate tumor-suppressive effect of connexin 32 gene in renal cancer cells.
Synonyms:
1-(tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;
1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine;
4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine;
1H-Pyrazolo[3,4-d]pyrimidin-4-amine (1-(1,1-dimethylethyl)-3-(4-methylphenyl);
Properties:
Appearance & Physical State: Off-white to grey solid
Density: 1.23g/cm3
Boiling Point: 478.8C at 760 mmHg
Melting Point: 205-207C
Flash Point: 243.4C
Refractive Index: 1.652
Vapor Pressure: 2.49E-09mmHg at 25°C
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