Decoglurant cas 911115-16-7

Name: Decoglurant cas 911115-16-7
Brand: Taizhou Crene Biotechnology Co., Ltd.

Price Negotiable

Price: Negotiable

MOQ: 1g

Delivery Time: Negotiable

Brand: Crene

Product Description

Chemical Information

Product name:Decoglurant	Purity:98% min
CAS NO:911115-16-7	Solubility:DMSO : 250 mg/mL (558.86 mM)
Molecular Formula:C₂₁H₁₁F₆N₅	Package:Package according to customer requirements.
Molecular Weight:447.336	Storage:Store at -20℃

Remarks

Decoglurant, also known as Ro 4995819, is a negative allosteric modulator of the mGlu2 and mGlu3 receptors which was under development by Roche for the adjunctive treatment of major depressive disorder. Decoglurant progressed as far as phase II clinical trials but was ultimately discontinued from further development due to disappointing efficacy results.

Chemical Name:

5-[2-[7-(trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]ethynyl]pyridin-2-amine

References

[1]. Wilkinson ST, et al. A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems. Drug Discov Today. 2019 Feb;24(2):606-615.