Zolmitriptan cas 139264-17-8

Zolmitriptan is a member of the triptan class agents with anti-migraine property. Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B expressed in intracranial arteries and 5_HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brain stem sensory nuclei. Receptor binding results in constriction of cranial vessels, reduction of the vessel pulsation and inhibition of nociceptive transmission, thereby providing relief of migraine headaches. Zolmitriptan may also relief migraine headaches by inhibition pro-inflammatory neuropeptide release.

Properties:

Appearance & Physical State: White or kind of white powder

Density: 1.217 g/cm3

Boiling Point: 563.3ºC at 760 mmHg

Melting Point: 136-141ºC

Flash Point: 294.5ºC

Refractive Index: 1.619

Vapor Pressure: 1.03E-12mmHg at 25°C

5-HT Receptor Inhibitors Related Products:

RS-127445; WAY-100635 Maleate; WAY-100635 maleate salt; Vortioxetine; Vortioxetine hydrobromide; Blonanserin; Intepirdine; Sertraline HCl; Lamotrigine; Azasetron hydrochloride; Iloperidone; Lasmiditan

• [1] Martin GR, et al. Br J Pharmacol,?997, 121(2), 157-164.
• [2] Le Grand B, et al. Eur J Pharmacol,?000, 397(2-3), 297-302.