Taizhou Crene Biotechnology Co., Ltd.
                                                                                                           
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China EGFR-IN-7 cas 2267329-76-8 for sale

EGFR-IN-7 cas 2267329-76-8

Price Negotiable
Price: Negotiable
MOQ: 1g
Delivery Time: Negotiable
Brand: Crene
Product Description
Chemical Information
Product name:EGFR-IN-7 Purity:98% min
CAS NO:2267329-76-8 Solubility:DMSO : 5 mg/mL (7.20 mM)
Molecular Formula:C32H41BrN9O2P Package:Package according to customer requirements.
Molecular Weight:694.6 Storage:-20ºC
Remarks

TQB3804, also known as EGFR-IN-7, is a selective and potent EGFR kinase inhibitor. TQB3804 displayed potent enzymatic activities for EGFRd746-750/T790M/C797S, EGFRL858R/T790M/C797S, EGFRd746-750/T790M, and EGFRL858R/T790M with IC50 of 0.46, 0.13, 0.26, and 0.19 nM respectively, and has similar enzymatic activity for EGFRWT (IC50 = 1.07) to Osimertinib. It also showed expected anti-proliferative activity in 4 cell lines, Ba/F3 (EGFRd746-750/T790M/C797S), NCI-H1975 (EGFRd746-750/T790M/C797S), PC9 (EGFRd746-750), and A431 (EGFRWT), with IC50 of 26.8, 163, 45, and 147 nM, respectively.

 

 

 

EGFR Inhibitors Related Products:

PD153035; Nazartinib; AZD3759; Erlotinib; CL-387785; AZ-5104; ARRY-380 analog; MTX-211; Osimertinib; Osimertinib mesylate; Olmutinib; Afatinib Dimaleate; Rociletinib

References
[1]. Aryl-phosphorus-oxygen compound as egfr kinase inhibitor.
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Company Taizhou Crene Biotechnology Co., Ltd.
Location Add: Economic Developed Zone of Taizhou Zhejiang China.

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