Duloxetine cas 116539-59-4

Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).

Properties:

Density: 1.158 g/cm3

Boiling Point: 466.2ºC at 760mmHg

Flash Point: 235.7ºC

Refractive Index: 1.627

Vapor Pressure: 7.23E-09mmHg at 25°C

Related Prodcuts:

Duloxetine hydrochloride; Duloxetine intermediate(132335-44-5; 116539-55-0); Iloperidone; Olanzapine; Clozapine; Agomelatine; Alosetron hydrochloride; Palonosetron hydrochloride; Lurasidone; Lurasidone hydrochloride; Ramosetron Hydrochloride; Atomoxetine hcl

[1]. De Berardis, D., et al., The effect of newer serotonin-noradrenalin antidepressants on cytokine production: a review of the current literature. Int J Immunopathol Pharmacol, 2010. 23(2): p. 417-22.

[2]. Wang, S.Y., J. Calderon, and G. Kuo Wang, Block of neuronal Na+ channels by antidepressant duloxetine in a state-dependent manner. Anesthesiology, 2010. 113(3): p. 655-65.