Tucatinib Irbinitinib Cas 937263-43-9
Chemical Information
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Product name:Tucatinib Irbinitinib |
Purity:98% min |
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CAS NO:937263-43-9 |
Solubility:DMSO : 50 mg/mL (104.05 mM) |
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Molecular Formula:C26H24N8O2 |
Package:Package according to customer requirements |
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Molecular Weight:480.521 |
Storage:-20ºC |
Remarks
Tucatinib, also known as Irbinitinib, ARRY-380 and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.
HER2 Inhibitors Related Products:
Poziotinib (HM781-36B); Mubritinib; Canertinib; Canertinib dihydrochloride; Lapatinib; Lapatinib ditosylate; Afatinib (BIBW2992); Afatinib (BIBW2992) Dimaleate; CUDC-101; TAK-285; Sapitinib
References
[1] P Lee, et al. Cancer Research(Poster Session Abstracts). 2009, 69(24 Suppl):Abstract nr 5104.
[2] SL Moulder, et al. AACR-NCI-EORTC. Nov 12-16, 2011, Abstr
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