INCB054828 Cas 1513857-77-6
Chemical Information
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Product name:INCB054828 Pemigatinib |
Purity:98% min |
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CAS NO:1513857-77-6 |
Solubility:DMSO : 40 mg/mL (82.05 mM) |
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Molecular Formula:C24H27F2N5O4 |
Package:Package according to customer requirements |
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Molecular Weight:487.50 |
Storage:-20ºC |
Remarks
Pemigatinib, also known as INCB054828, is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. FGFR inhibitor INCB054828 binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells.
FGFR Inhibitors Related Products:
Infigratinib; PD173074; AZD4547; Danusertib; Brivanib alaninate; Lenvatinib; Lenvatinib mesylate; Nintedanib esylate; BLU9931; SKLB610; Roblitinib
References
[1] Robert Roskoski Jr. Pharmacol Res. 2020 Jan;151:104567.
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