LOU064 Remibrutinib cas 1787294-07-8
| Product name:Remibrutinib | Purity:98% min |
| CAS NO:1787294-07-8 | Solubility:DMSO : 100 mg/mL (197.03 mM) |
| Molecular Formula:C27H27F2N5O3 | Package:Package according to customer requirements |
| Molecular Weight:507.53 | Storage:-20ºC |
Remibrutinib (LOU064) is a potent, highly selective covalent inhibitor of bruton tyrosine kinase (BTK) with IC50 of 1.3 nM, 2.5 nM and 18 nM for BTK, FcγR-induced IL8 and anti-IgM/IL4-induced CD69, respectively. Remibrutinib (LOU064) exhibits an exquisite kinase selectivity due to binding to an inactive conformation of BTK and has the potential for the treatment of autoimmune diseases.
Interleukins Inhibitors Related Products:
Aprepitant; A-740003; Resatorvid; T-5224; YM-90709
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[2]. Kolkhir P, et al. New treatments for chronic urticaria. Ann Allergy Asthma Immunol. 2019 Aug 23.
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