ML-246 Metarrestin Custom Chemical Synthesis Cas 1443414-10-5
Price:
Negotiable
MOQ:
1g
Delivery Time:
Negotiable
Brand:
Crene
Product Description
ML-246 Metarrestin Custom Chemical Synthesis Cas 1443414-10-5
Chemical Information
| Product name:Metarrestin (ML246) | Purity:98% min |
| CAS NO:1443414-10-5 | Solubility:DMSO : 31.25 mg/mL (65.84 mM) |
| Molecular Formula:C31H30N4O | Package:Package according to customer requirements. |
| Molecular Weight:474.596 | Storage:-20 ℃ |
Remarks
Metarrestin (ML246) is an orally active, specific perinucleolar compartment inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models.
Related Prodcuts:
Gemcitabine HCL; Bleomycin Sulfate; Temozolomide; Carmustine; CX-5461; Nelarabine; Cladribine; Trifluridine; Daptomycin; Fludarabine Phosphate
References
[1]. Vilimas T, et al. Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer. Cancer Chemother Pharmacol. 2018 Dec;82(6):1067-1080.
[2]. Frankowski KJ, et al. Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis. Sci Transl Med. 2018 May 16;10(441).
[2]. Frankowski KJ, et al. Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis. Sci Transl Med. 2018 May 16;10(441).
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Company
Taizhou Crene Biotechnology Co., Ltd.
Location
Add: Economic Developed Zone of Taizhou Zhejiang China.