Epiblastin A cas 16470-02-3
Price:
Negotiable
MOQ:
1g
Delivery Time:
Negotiable
Brand:
Crene
Product Description
Chemical Information
| Product name:Epiblastin A | Purity:98% min |
| CAS NO:16470-02-3 | Solubility: |
| Molecular Formula:C12H10ClN7 | Package:Package according to customer requirements |
| Molecular Weight:287.708 | Storage:-20 ℃ |
Remarks
Epiblastin A is an ATP-competitive inhibitor of the casein kinase 1 (CK1) isoforms α, δ, and ε (IC50s = 8.9, 0.5, and 4.7 μM, respectively). [1] It is selective for CK1α, CK1δ, and CK1ε at concentrations below 10 μM, however, it also inhibits BRSK1, EEF2K, EGFR, MNK-2, and RIPK2 (IC50s = 24-45 μM). Epiblastan A reduces immunoprecipitation of CK1α, CK1δ, and CK1ε from HCT116 cell lysates in a concentration-dependent manner. It induces reprogramming of mouse epiblast stem cells (mEpiSCs) into embryonic stem cells (ESCs) 8-fold more efficiently than triamterene .
References
[1]. Ursu, A., Illich, D.J., Takemoto, Y., et al. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of Casein Kinase 1. Cell Chem. Biol. 23(4), 494-507 (2016).
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Company
Taizhou Crene Biotechnology Co., Ltd.
Location
Add: Economic Developed Zone of Taizhou Zhejiang China.